MAPT and Alzheimer disease: Furthermore, tau(297-391) overlaps with the core of filaments resolved from ex vivo filaments by cryo-EM (Fitzpatrick et al., 2017), was shown to form PHF that resemble those observed in AD patients (Al-Hilaly et al., 2020), and later confirmed by cryo-EM to form an architecture identical to those from AD brain under certain conditions (Lövestam et al., 2022).