Nevertheless, the AD fibril core represented by tau(297-391) is the binding site of powerful inhibitors of tau aggregation such as epigallocatechin gallate (EGCG) and methylthioninium, which are also able to inhibit and disaggregate preformed tau filaments (Wischik et al., 1996; Seidler et al., 2022). The gene discussed is MAPT; the disease is Alzheimer disease.