In humans, SHANK3 gene (22q13.3) deletion triggers neurodevelopmental disorders like Phelan–McDermid syndrome (PMS), characterized by autistic like behaviors, hypotonia and delayed or absent speech (Bonaglia et al., 2001; Phelan et al., 2001; Phelan, 2008; Phelan and McDermid, 2012). The gene discussed is SHANK3; the disease is premenstrual tension.