BDNF and Mental deterioration: A reduction in hippocampal levels of BDNF is associated with cognitive decline, which has been reported in numerous rodent models of cognitive declines, such as Sprague–Dawley rats subjected to 48 h of SD (Wadhwa et al., 2017), Wistar rat offspring whose mothers experienced chronic mild stress during pregnancy (Guan et al., 2016), and Sprague–Dawley rats who experienced maternal separation (Ohta et al., 2017).