ABCA1 and age-related macular degeneration: The contribution of impaired cholesterol homeostasis to AMD pathology was further supported by seminal work by the Apte and Grimm labs: mutant mice lacking the cholesterol efflux transporters ATP-binding cassette transporter A1 and G1 specifically from macrophages, photoreceptors, or RPE all develop lipid-rich retinal deposits and associated retinal/RPE dysfunction mimicking AMD.58, 59, 60 These mouse models highlight a possible role for immune dysregulation and lipid dyshomeotasis in AMD pathogenesis and may have utility in future studies to test novel therapeutic strategies.