NOTCH3 and cerebral arteriopathy with subcortical infarcts and leukoencephalopathy: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common hereditary cerebral small vessel disease (CSVD), is caused by pathogenic mutations in NOTCH3 located on chromosome 19p13 (Joutel et al., 1996).