• In SCI, Th1 cells expressed TNF-α and IL-6 were upregulated and promote the M1 macrophages formation and activation, and thus deteriorate the lesion damage (Hirai et al., 2013). • Trauma induced autoimmunity promote the MBP-T cells transfer into Th2 subtype which are beneficial for SCI (Hu et al., 2016). • Treg cells expressed IL-10 inhibits the M1 microglia transformation (Liesz et al., 2013). • Treg cells mediated neuroprotection is subject to the constraints of time and space (Raposo et al., 2014). This evidence concerns the gene TNF and Autoimmunity.