More recently, also using brain tissue from AD patients, Chung et al. (2022) explored genomics and transcriptomics data and found an association of AD with genetic variants in MGMT (O6-methylguanine-DNA methyltransferase, which is involved in DNA damage repair function) amongst women lacking the APOE ε4 allele, the most important genetic risk factor in sporadic (non-familial) AD. Here, APOE is linked to Alzheimer disease.