Regarding the associations between the expression levels of specific LPA receptors and AD, no direct associations have been reported, and only LPA1 has been reported to facilitate the brain delivery of donepezil (Choi et al., 2021); however, considering the important roles of LPA in the field of neurology, as described in the Introduction section (Hao et al., 2020), the present results suggest that the LPA receptors might be potential therapeutic targets for AD. The gene discussed is LPAR1; the disease is Alzheimer disease.