APOE and Alzheimer disease: Interestingly, the LDLR-related protein 1 (LRP1) has been shown to interact with both APOE ε4 mediated Aβ-pathology and leptin signaling (Shinohara et al., 2017), thus providing a common link for both pathways and a potential target for future research in the context of the intricate relationship between AD, adiposity and energy metabolism.