5. In addition to the evidence-based treatments above, the leaky RyR2 channels, HMGB1 and kynurenine pathway (KP) have been found to be potential therapeutic targets for improving COVID-19-related memory symptoms (Street, 2020; Cysique et al., 2022; Reiken et al., 2022). The gene discussed is RYR2; the disease is COVID-19.