Based on the in vivo experiment in the ICV-STZ rat model of AD, modulation of the PI3K/Akt/GSK3β signaling pathway could diminish oxidative stress, neuro-inflammation, and apoptosis, Moreover, amyloid plaque number and phosphorylated tau expression were marked decrement (Nishizaki, 2018). The gene discussed is GSK3B; the disease is Alzheimer disease.