A chimeric human HER2/neu fusion protein (ADXS31-164, also now known as ADXS-HER2 and OST-HER2) was tested in dogs with a histopathological and immunohistochemical diagnosis of HER2/neu OSA, following amputation/limb sparing surgery and treatment with carboplatin (153). Here, ERBB2 is linked to obstructive sleep apnea syndrome.