No cure yet; Levodopa and dopamine agonists (such as Ropinrole and Pramipexole) (to reduce motor symptoms); MAO-B inhibitors (e.g., Safinamide or Xadago to alleviate motor symptoms); Antidepresssants (to treat PD-associated depression); Deep brain stimulation (to improve motor function and reduce tremors); Stem cell therapy (to repair or replace damaged dopaminergic neurons). This evidence concerns the gene MAOB and major depressive disorder.