MAPT and Brain atrophy: MRI: Brain atrophy in the medial temporal lobe (hippocampus, entorhinal cortex and parahippocampal gyrus) and enlarged ventricles; DTI: White matter decline (diffusion anisotropy reduction); fMRI: Altered functional network connectivity and hippocampal activity; PET: Abnormal beta-amyloid and tau aggregation (56)