Since pathological proteins such as beta-amyloid, tau, alpha-synuclein and transactive response DNA binding protein 43 (TDP-43) in AD, PD or ALS act like prions in misfolding, aggregating, seeding, and spreading in the brain, these neurodegenerative disorders have been called prion-like diseases (115–117). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.