CSF: May be normal; elevated S100B proteins in 84% sCJD patients; CSF 14-3-3 protein positive for 86% sCJD patients, but only in half of vCJD patients (64). The presence of prion PrPSc detected by RT-QuIC with ~89% accuracy (65). EEG: generalized periodic sharp wave pattern in 50% sCJD (66). Here, S100B is linked to variant Creutzfeldt-Jakob disease.