Up to now, there have been three clinical studies regarding the relationship between serum HIF-1α levels and the prognosis of humans with acute brain injury, where elevated serum HIF-1α levels were highly correlated with cerebral infarction size in 40 patients with acute ischemic stroke (22), were independently associated with admission Glasgow outcome scale scores and 90-day poor outcome in 97 patients with acute spontaneous intracerebral hemorrhage (23), and were independently predictive of 90-day poor prognosis in 104 patients with severe traumatic brain injury (24). This evidence concerns the gene HIF1A and injury.