This work suggested that IFN-1 has a specific relationship with unique signaling cascades, focusing on the IFN response to antiviral effectors, such as the interferon-inducible transmembrane (IFITM) and the 2′-5′-oligoadenylate synthase (OAS) family genes in both AD and COVID-19 (15). The gene discussed is SMOC1; the disease is Alzheimer disease.