The first specific mechanistic indication that the intracellular lifecycle of SARS-CoV-2 may be linked with neurodegeneration, and specifically with tauopathies, came from a brain organoid infection model; SARS-CoV-2 neuroinfection was quiescent, causing neuronal apoptosis with hyperphosphorylated tau as its hallmark (16). This evidence concerns the gene MAPT and infection.