Clinical, pathological and radiological manifestations of this SARS-CoV-2 associated neurocognitive disorder (SAND) have outlined its significant overlap with neurodegenerative dementia (2), which extends to biomarkers in some individuals to include biomarkers consistent with neurodegenerative diseases such as Alzheimer's disease (AD), including beta amyloid oligomers (Aβ), tau, neurofilament light chain (Nfl) and others (3, 4). Here, NEFL is linked to early-onset autosomal dominant Alzheimer disease.