TBXT and Alzheimer disease: The lossof cholinergic neurons in the basal frontal cortex, intracellularneurofibrillary tangles caused by τ-protein hyperphosphorylation,extracellular β-amyloid (Aβ) plaques, and oxidative stressare the most significant pathogenic characteristics of AD.8,9 Insufficient cholinergic transmission, which causes the emergenceof cognitive, functional, and behavioral symptoms, is one cause thatis given a significant role in AD.