ACHE and Alzheimer disease: On the other hand,the most cutting-edge therapeutic approach now being used is basedon the “one drug–multiple targets” strategy,which recommends using drugs with multiple actions at various targetsites.14,15 A promising approach for treating complicatedand multifaceted neurodegenerative illnesses is a multitarget directedligand strategy that targets monoamine oxidase B (MAO-B).16 In AD, this strategy primarily uses dual inhibitorsof MAO and acetylchoninesterase (AChE).