The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) can be used as a monitoring indicator of preeclampsia (PE), which is a kind of hypertensive disorder complicating pregnancy and seriously endangers the health of mothers and infants, with unpredictable outcomes (70). This evidence concerns the gene FLT1 and hypertensive disorder.