Similar to DUXAP8, lncRNA PVT1 was considered as involved in the ferroptosis progress, it may regulate ferroptosis through miR-214-mediated TFR1 and TP53 expression (Lu, Xu & Lu, 2020), it was identified as one of the ferroptosis-related lncRNAs to construct a panel for predicting tumor progression, microenvironment (He et al., 2021), and radiotherapy response (Zheng et al., 2021) in glioma; in liver cancer, PVT1 is involved in the regulatory mechanism of lncPVT1/miR-214-3p/GPX4 axis and plays a role in ketamine suppressing the viability of liver cancer cells and inducing ferroptosis. The gene discussed is TP53; the disease is central nervous system cancer.