Spp1–integrins/Cd44 were present only in the 6-month samples, and Cxcl4–Cxcr3 and Entpd–Adora2a were present only in the 3-month samples, while Cxcl16–Cxcr6 expression gradually decreased between T cells and endothelial cells as infection progressed (Figure 6B). The gene discussed is SPP1; the disease is infection.