The expression heatmaps of the endothelial cell genes in the sample revealed that DCN and IFN-activated endothelial cell marker genes (Irf8, Rsad2, Ifit1, Ifit3, Iigp1) were significantly upregulated at 1 month post-infection as compared with the WT group (Figure 2I). The gene discussed is IRF8; the disease is infection.