Cd274 and Zbtb32 negatively regulate immunity (25–27), and S100a4, Rap1gap, Armc3, and Prkar2b promote tumor metastasis (28–30), This was consistent with the emergence of immunosuppression in the later stages of E. granulosus infection and with the hydatid cyst metastasis. The gene discussed is RAP1GAP; the disease is neoplasm.