RUNX3 and infection: The intersection of the downstream genes of Runx3 and Rora, and the top 200 specific genes was S100a4. It has been well-documented that S100a4 is critical for macrophage polarization to an immunosuppressive type (55), suggesting that Cebpe, Runx3, and Rora might act as core TFs in the regulation of angiogenesis immunosuppression and liver tissue 6 months post-infection.