Cytokines from the tumor microenvironment such as transforming growth factor beta (TGF-β) and interleukin 10 (IL-10) are known cytokines to promote tumor survival but also to induce immunosenescence by upregulating BCL-2 expression in tumor and immune cells as well as the expression of co-inhibitory receptors (preliminary data from our group DOI: 10.1101/2020.12.15.422949, 10.1101/2021.02.26.432955). This evidence concerns the gene BCL2 and neoplasm.