In order to study the effect of BLM inhibition on MM cell survival, one ML216-resistant (XG1; IC50 = 13.2 μM) and two ML216-sensitive (XG19 IC50 = 1.2 μM; XG2 IC50 = 4.9 μM) HMCLs were chosen. The gene discussed is BLM; the disease is Miyoshi myopathy.