At the same time, inhibiting the expression of glucocorticoid receptors (GR) significantly increased the expression of proinflammatory cytokines (IL-6, IL-1β, and TNF-α) and decreased the brain-derived neurotrophic factor/pro-myosin receptor kinase B (BDNF/TrkB) signaling in the mice brain, which can increase the infarct size and worsen neurobehavioral deficits in ischemic stroke (142). Here, TNF is linked to ischemic stroke.