GH treatment enhanced the regulation of excitatory synaptic transmission and plasticity in the aged rat hippocampus by activating N-methyl-D-aspartate receptor (NMDAR)-dependent basal synaptic transmission and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPA-R)-dependent basal synaptic transmission, which altered the course of cognitive decline (85). Here, GH1 is linked to Mental deterioration.