To address this evidence gap, we integrated acute transcriptomic changes (bulk RNA-sequencing) of peripheral whole blood observed during anaphylaxis (i) in patients presenting to the hospital emergency department (ED) with acute anaphylaxis triggered mostly by insect stings, (ii) in peanut-allergic patients undergoing double-blind placebo-controlled food challenge (DBPCFC), and (iii) in a study of iIL9Tg mouse model using the passive antigen-induced anaphylaxis model which mimics food-induced IgE-mediated anaphylaxis (12, 13). The gene discussed is IGHE; the disease is anaphylaxis.