(11), five of six, specifically PADI4, IL1R2, PPP1R3D, KLHL2, and ECHDC3, but not LTB4R, were found to be dysregulated in ED and DBPCFC studies, supporting the importance of those genes in human anaphylaxis and the relevance of previous results (11). The gene discussed is KLHL2; the disease is anaphylaxis.