However, to our knowledge, this is the first report of integrated transcriptomic analysis of human anaphylaxis (ED patients with acute reaction, predominantly to Hymenoptera venom and patients with peanut allergy undergoing DBPCFC to peanut) and iIL9T mouse model, which mimics food-induced IgE-mediated anaphylaxis. Here, IGHE is linked to peanut allergic reaction.