In China, 65 patients with MSMD in 20 publications (35, 55–72) were described, along with 9 gene mutations (IFNGR1, IFNGR2, ISG15, IL12B, IL12RB1, STAT1, TYK2, NEMO, CYBB) were noted. The gene discussed is IL12RB1; the disease is Mendelian susceptibility to mycobacterial diseases.