Only the CD11ahiCD49dhi CD4 T cells, but not the CD11aloCD49dlo subset, produced IFN-γ when stimulated with mCAR12/mCDK12 peptides in vitro (Supplementary Figures S4B, C), suggesting that CD11ahiCD49dhi T cells represent an antigen-experienced subpopulation in the KPC4580P tumor. The gene discussed is IFNG; the disease is neoplasm.