During early sepsis, lipopolysaccharides (LPS) is recognized by toll-like receptor 4 (TLR4) of macrophages, which activate the nuclear factor-κB (NF-κB) pathway and mitogen-activated protein kinase (MAPK) pathway, causing inflammation-active mediators (such as IL-1, IL-6, IL-18, TNF-α) releasing and facilitating the clearance of pathogenic microorganisms (28). This evidence concerns the gene TLR4 and Sepsis.