It is noteworthy that CXCL10 (produced mainly by astrocytes) might have a major neuropathogenic role; for example, CXCL10-/- and CXCR3-/- mice challenged with P.berghei ANKA or T.brucei control the infection more readily and are resistant to the neurologic disorder (11). The gene discussed is CXCL10; the disease is infection.