However, macrophages in metastatic tumors had high expression of HLA-DQA2, KRT15, S100A8, and S100A9, and GO analysis showed that lipid catabolic process, myeloid leukocyte migration, and the regulation of cell activation were highly enriched (Supplementary Figure S8B; Supplementary Table S1). Here, S100A8 is linked to metastatic neoplasm.