ECM1 and neoplasm: Compared to cells in tumor 3 that expressed increased epithelial markers like CDKN2A, CRB3, KRT13, and KRT6, tumor cells in metastatic LN exhibited high expression of mesenchymal markers like CDH3, ECM1, TGFB1, WARS, and VIM, indicating that tumor metastasis was related to EMT (Figure 2K; Supplementary Table S1).