In summary, the current study indicates that polymorphisms of METTL14 rs62328061 and WTAP rs11752345 may contribute to increased PTB susceptibility, and several SNPs in METTL3, METTL14, and WTAP genes were associated with the clinical features including drug resistance, DILI, and leukopenia in PTB patients. Here, METTL14 is linked to Decreased total leukocyte count.