Endothelial cell proliferation is reduced and migration is diminished in response to IFN-γ, which promotes the secretion of IFN-Inducible Protein-10 (IP-10) and Monokine Induced by Interferon Gamma (MIG), which react with chemokine receptor 3 to inhibit endothelial cell proliferation and tumor angiogenesis (48, 49), thereby normalizing vasculature and promoting effector T cell infiltration. This evidence concerns the gene IFNG and neoplasm.