TNC and Granuloma: Unsurprisingly, the gene expression profile of infected animals was skewed towards fibrosis and scarring with increased Col1a (seen in all granulomas studied, gene 19 Table 1), increased Tnc (tenacin, increased in D21 vs. D7 granulomas, gene 77 Table 2) and late deposition of Fn1 (fibronectin, increased in D21 vs. D7 granulomas, gene 50 Table 2) (64).