MMP12 and Granuloma: This ratio was low in all granulomas but more so in the trickle D21 granulomas: Mmp12 and Mmp13 are increased in both types of D21 granulomas (genes 33 and 70 Table 2), while Timp3 is increased 1.75-fold in trickle vs. bolus D21 granulomas (Supplementary Table 1).