found a decrease in glucose uptake and the upregulation of immunosuppressive molecules (IFN-γ and CD40L) in CD4+ T cells in melanoma and identified the glycolytic enzyme hexokinase 2 (HK-2) in tumors and glycolytic metabolite phosphoenolpyruvate carboxy kinase 1 (PET-1) in T cells as key regulators in the interaction (23). The gene discussed is HK2; the disease is melanoma.