To identify stroke-related changes in immunodeficient mouse models, we induced a photothrombotic stroke in the right sensorimotor cortex in (1) C57BL/6J wildtype (WT) mice (2) C57BL/6J WT mice that were continuously immunosuppressed with tacrolimus (WT-Tacr); as well as genetically immunodeficient (3) Rag2-/- and (4) NSG mice (Figure 1A). The gene discussed is RAG2; the disease is Stroke.