Nonetheless, the underlying mechanisms of how e-MDSCs regulate cancer and autoimmunity remain unclear (Table 1) (29).M-MDSCs mainly mediate inflammatory response by secreting relatively high iNOS and relatively low ROS, while PMN-MDSCs primarily regulate tumors by secreting relatively high ROS and relatively low levels of iNOS (20). The gene discussed is NOS2; the disease is Autoimmunity.