Conversely, In multiple mouse models of RA, adoptive transfer of MDSCs reduced the relative ratio of Th1 and Th17 cells, accompanied by an increase in Treg numbers, and decreased serum inflammatory factors including TNF-α, IL-6, and IL-17, resulting in remission of clinical and histological manifestations of RA [118, 119, 146]. The gene discussed is TNF; the disease is rheumatoid arthritis.