We found that these genes were greatly enriched in tumorigenesis and development-related signaling pathways, such as epithelial-mesenchymal transition, MAPK signaling, P53 signaling, hypoxia, and cytokine receptor interaction (Figure S2B), suggesting that these CRD scores are closely related to the malignant progression of HCC. This evidence concerns the gene TP53 and hepatocellular carcinoma.