KEGG enrichment analysis suggested that immune-mediated signaling pathways, various human diseases including multiple virus infections, alcoholic liver disease, and autoimmune disease, and classical signaling pathways including the TNF signaling pathway, cytokine–cytokine receptor interaction, NF-kappa B signaling pathway, and MAPK signaling pathway were closely related to these immune microenvironment-related DEGs. The gene discussed is TNF; the disease is autoimmune disease.