Moreover, the baseline frequency of IL-21 positive CD8+ central memory T cells was also significantly correlated with KSHV infection of plasma cells at 3dpi (r=0.76, p=0.03; σ=0.76, p=0.04) and negatively correlated with infection of naïve B cells (r=-0.72, p=0.04) (Figures 6C, D). Here, IL21 is linked to infection.