Despite the specific mechanisms underlying the role of SCFAs in MM being unclear, SCFAs often exert tumor suppressive effects by downregulating the NF-κB pathway, inhibiting inflammatory factors such as IL-1β, IL-6, IL-8, and TNF-α, and inducing the expression of IL-10 anti-inflammatory cytokines. The gene discussed is NFKB1; the disease is Miyoshi myopathy.