Although gene expression programs seem to be driven by primary genetic events, there is a sequence of molecular events that are caused by these abnormalities, including secondary genetic abnormalities, as well as genetic events of monoclonal gammopathy of undetermined significance (MGUS) and MM progression such as aberrant nuclear factor-κB (NF-κB) signaling (38). Here, NFKB1 is linked to Miyoshi myopathy.