In a co-model for cholestatic liver injury and colitis in the form of multidrug resistance protein 2 (MDR2) knockout mice treated with DSS, it was found that the bile acid UDCA reduced the severity of colitis and downregulated colitis susceptibility protein mucosal addressin-cell adhesion molecule 1(MAdCAM-1) (103). The gene discussed is ABCB4; the disease is colitis.