After administration of the HIF-1α inhibitor, the level of HIF-1a protein and gene expression, IL-6, INF-α were reduced, and the level of BNIP3L protein and gene expression was increased, and the apoptosis damage of hippocampus neurons and mitochondrial damage were alleviated, and cognitive function of sepsis mice and survival rate improved. This evidence concerns the gene BNIP3L and Sepsis.