HIF1A and Sepsis: Compared with the control group and the sham group, the HIF-1α protein (Figure 5A) and mRNA (Figure 5C) expression of hippocampus was up-regulated, and BNIP3L protein (Figure 5B) and mRNA expression(Figure 5D) was down-regulated in the sepsis group (p < 0.05); after administration of echinomycin to sepsis mice, the HIF-1α protein(Figure 5A) and mRNA (Figure 5C) was lower than the sepsis group (p < 0.05) and the BNIP3L protein (Figure 5B) and mRNA (Figure 5D) was higher than the sepsis group(p > 0.05).