Compared with the control group and the sham group, the HIF-1α protein expression was up-regulated, and the BNIP3L protein expression was down-regulated of mitochondria of the hippocampus in the sepsis group (p < 0.05); after administration of echinomycin to sepsis mice, the expression of HIF-1α was down-regulated(p < 0.05) and the expression of BNIP3L protein expression was increased(p > 0.05) (Figure 10). The gene discussed is HIF1A; the disease is Sepsis.