Our recent study has found that gallic acid, a small molecule compound found in traditional Chinese medicine, when combined with anti-PD-1 antibody, significantly dampen tumour- infiltrating FOXP3+ Treg cell function by impairing PD-1/PD-L1 signaling and Foxp3 stability in colorectal cancer (CRC) model (35). The gene discussed is FOXP3; the disease is colorectal carcinoma.