Previous investigations showed that an upregulation for TRPC3 and 6 in human patients suffering from IPAH (Yu et al., 2004) as well as for TRPC1 and 6 in mice exposed to chronic hypoxia (Malczyk et al., 2013; Xia et al., 2014). Here, TRPC1 is linked to idiopathic pulmonary arterial hypertension.