ADL, activities of daily living; NYHA, New York Heart Association; eGFR, estimated glomerular filtration rate; LVEF, left ventricular ejection fraction; BNP, brain natriuretic peptide; NT-proBNP, N-terminal prohormone of brain natriuretic peptide; MRA, mineralocorticoid receptor antagonist; AF, atrial fibrillation; IHD, ischemic heart disease. The gene discussed is NPPB; the disease is myocardial ischemia.