VEGFA and breast cancer: It makes up approximately 15-20 percent of all breast cancers [3-5]. It is made up of an immunological tumor microenvironment (TME) with high production of vascular endothelial growth factors (VEGF), tumor-infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), extracellular matrix (ECM), connective tissue, stromal fibroblasts, and cytokines that stimulate the growth and migration of tumor cells, this TME plays a dual function in the development, progression, and metastasis of tumor [6-9].