MYC and cancer: In the 12 remaining papers that used metformin in PCa mouse models, three papers used models of spontaneous PCa including the TRAMP model47, 55 or a Hi‐Myc mouse model (where c‐myc was overexpressed under the control of the probasin promoter)54 to assess the effect of metformin on prostatic intraepithelial neoplasia and cancer lesion development.