Universally, metformin was reported to reduce tumour initiation, with reduced prostatic intraepithelial neoplasia lesions,47, 54 reduced metastases consistent with decreased expression of c‐myc and EMT hallmark genes,54, 62 and reduced tumour growth for both subcutaneous and intraprostatic xenograft PCa models.40, 41, 42, 43, 44, 45, 46, 47, 54. Here, MYC is linked to neoplasm.