The leukemia cells in the EMI group showed abnormally low expression of miR-3677-5p but high expression of CXCL12 and CXCR4 mRNA, indicating that the miR-3677-5p/CXCL12 axis may be closely related to the occurrence of EMI in monocytic leukemia. This evidence concerns the gene CXCR4 and leukemia.