Tuft cell-like tumors with co-expression of POU2F3, GFI1B, and KIT were identified among pulmonary squamous cell carcinomas, adenocarcinomas, and large cell neuroendocrine carcinoma, and new molecular subsets were delineated by their tuft cell-like signatures among the lung cancer histotypes (Yamada et al., 2021). The gene discussed is POU2F3; the disease is lung carcinoma.