In addition, POU2AF2 and POU2AF3 were identified as novel vulnerabilities in tuft cell-like SCLC and POU2AF3 functioned as a co-activator for POU2F3 to drive the transcriptional program critical for tuft cell-like SCLC (Zhou et al., 2022). This evidence concerns the gene POU2AF2 and small cell lung carcinoma.