Similarly, IL-17RB expression was also found in human colorectal cancer stem cells instead of normal stem cells by genealogical tracking, and long-term ablation of IL-17RB resulted in the inhibition of cancer stem cells growth in vivo, which all validated the implication of IL-17RB+ cancer stem cells as clinical targets for cancer therapy (Goto et al., 2019). Here, IL17RB is linked to cancer.