Based on the critical role of POU2F3 in lung cancer, it was uncovered that binding between POU2F3 and its coactivators (OCA-T1, OCA-T2) was essential in tuft-cell-like small-cell lung cancer, and POU2F3–OCA-T complex was the master regulator for identity of tuft cells and a potential target in treating tuft-cell-like small-cell lung cancer (Wu et al., 2022). This evidence concerns the gene POU2F3 and lung cancer.