The core mechanism underlying amino acid metabolic adaptations in cancer cells to grow in a nutrient-deficient tumor microenvironment (TME) was recently reported, and LYSET (TMEM251) and other amino acid utilization-associated genes (ATF4, TSC2, VPS18, RAB7A, SLC7A5, SLC3A2, TGFBRAP1, GNPTAB, and GCN2) have been primarily screened out mainly through CRISPR-Cas9 based high-throughput method (Pechincha et al., 2022). Here, LYSET is linked to cancer.