CD4 and neoplasm: Interestingly, positive correlations among CLST, liver-resident CD4+ T naïve-like cells (CD4+TLR-NL), acquisition of a TH17 polarization state (CD4+TLR-NL), CD4+TEM-TH1/TH17, and immune checkpoints (ICs) indicated their cross-talk in the tumor tissue of HBV-HCC (Figure 4A).