Our study showed that there is dysfunction of skeletal muscle mitochondria in cancer cachexia, including the occurrence of mitochondria, mitochondrial fission/fusion, and abnormal expression of mitochondrial complexes, whereas the number, morphology, and function of mitochondria are impaired, and creatine supplementation corrects this abnormal change, restores mitochondrial morphology and function to some extent, activates Akt, inhibits the UPS and ALP systems, and thereby protects skeletal muscle from degradation. Here, AKT1 is linked to cancer.