ELANE and respiratory system disorder: Patients with various respiratory disorders have remarkably elevated levels of neutrophil elastase in their bronchoalveolar lavage, sputum, and fluid (Oriano et al., 2020; Keir and Chalmers, 2022; Kummarapurugu et al., 2022; Margaroli et al., 2022); as a result, this enzyme contributes to tissue destruction, which is primarily linked to respiratory disorders (Chua and Laurent, 2006; Pham 2008).